Milos Simic

This paper develops a spike-in probe-enhanced scRNA-seq method to track and profile synNotch-CAR-T cells in vivo, revealing tissue-specific activation and transcriptional states.

This paper engineers T cells with synthetic receptors that activate only in the lung, demonstrating RAGE as a lung-specific target for targeted therapies.

The paper uses synthetic costimulatory domains and machine learning to identify design rules for CARs that enhance cytotoxicity and stemness.

This paper identifies endocytic trafficking as a mechanism for presynaptic opioid tolerance, showing that receptor cycling and phosphorylation-dependent endocytosis contribute to tolerance development.