Chemo-mechanotherapy of fibrosis: dynamic control of biological materials through tissue-architecture-dependent crosslink disruption
Wenyu Kong, Meiyue Song, Xiangjun Peng, Lu Bai, Jia’nan Zeng, Kaini Liang, Yuhong Jin, Jiaxin Wang, Xue Wang, Yuxuan Huang, Yudi Niu, Lyu Zhou, Xi‐Qiao Feng, Chen Wang, Guy M. Genin, , Yanan Du
This study shows that mechanical stretching can disrupt pathological crosslinks in fibrotic tissues, reversing fibrosis in mice when combined with pharmacological treatment.
bioRxiv · Sep 1, 2025 · PreprintBioengineering