Author

Willem Michael

Ludwig-Maximilians-Universität München

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Bart De StrooperiD· 1 shared Bert HoubeniD· 1 shared Brajabandhu PradhaniD· 1 shared Daan MoecharsiD· 1 shared Dietmar Rudolf ThaliD· 1 shared Dries T’SyeniD· 1 shared Frédéric RousseauiD· 1 shared Giulia AlbertiniiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Bart De StrooperORCID

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1 paper

Recent·Most cited

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency

Katerina Konstantoulea, Meine Ramakers, Sarah Catherine Borrie, Dries T’Syen, Daan Moechars, Małgorzata Alicja Śliwińska, Brajabandhu Pradhan, Giulia Albertini, Grigoria Tsaka, Bert Houben, Mark W. E. J. Fiers, Maarten Dewilde, Dietmar Rudolf Thal, Willem Michael, Jonas J. Neher, , Joost W. H. Schymkowitz

This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.

bioRxiv · Oct 11, 2025 · PreprintBiochemistry