Giulia Albertini

This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

This study shows microglia initially seed amyloid plaques in Alzheimer's disease but later help compact them, with genetic and pharmacological manipulation affecting plaque formation.

The paper uses single-molecule detection and super-resolution imaging to analyze how four monoclonal antibodies bind to beta-amyloid aggregates, finding Lecanemab has superior binding properties.

This study shows that serotonin signaling through microglial 5-HT2B receptors during early development is critical for normal neuronal circuit maturation and social behavior.