Two-step mechanism of J-domain action in driving Hsp70 function
Bartłomiej Tomiczek, Wojciech Delewski, Łukasz Nierzwicki, Milena Stolarska, Igor Grochowina, Brenda A. Schilke, Rafał Dutkiewicz, Marta A. Uzarska, Szymon J. Ciesielski, Jacek Czub, Elizabeth Anne Craig, Jarosław Marszałek
The paper investigates the two-step mechanism of J-domain action in Hsp70 function, revealing how JDPs perturb Hsp70's intramolecular network and enable ATP hydrolysis through conserved and variable residues.
PLoS Computational Biology · Jun 1, 2020Peer-reviewedMolecular Biology