Author

Brenda A. Schilke

University of Wisconsin–MadisonORCID 0000-0002-1288-7724Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Bartłomiej TomiczekiD· 2 shared Elizabeth Anne CraigiD· 2 shared Jacek CzubiD· 2 shared Jarosław MarszałekiD· 2 shared Milena StolarskaiD· 2 shared Agnieszka A. KlosowskaiD· 1 shared Aneta SzymańskaiD· 1 shared Dominik PurzyckiiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersEvolutionary Biology

Bartłomiej TomiczekORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Origin of Class B J-domain proteins involved in amyloid transactions

Przemyslaw Domanski, Milena Stolarska, Katarzyna Kalinowska, Dominik Purzycki, Brenda A. Schilke, Hubert Wyszkowski, Marcin Pitek, Aneta Szymańska, Katarzyna Bury, Jacek Czub, Agnieszka A. Klosowska, Elizabeth Anne Craig, Jarosław Marszałek, Bartłomiej Tomiczek

This paper investigates the evolutionary origin of class B J-domain proteins, showing they evolved from class A duplicates by losing their zinc finger domain, enabling new functions in amyloid aggregate regulation.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedEvolutionary Biology

Two-step mechanism of J-domain action in driving Hsp70 function

Bartłomiej Tomiczek, Wojciech Delewski, Łukasz Nierzwicki, Milena Stolarska, Igor Grochowina, Brenda A. Schilke, Rafał Dutkiewicz, Marta A. Uzarska, Szymon J. Ciesielski, Jacek Czub, Elizabeth Anne Craig, Jarosław Marszałek

The paper investigates the two-step mechanism of J-domain action in Hsp70 function, revealing how JDPs perturb Hsp70's intramolecular network and enable ATP hydrolysis through conserved and variable residues.

PLoS Computational Biology · Jun 1, 2020Peer-reviewedMolecular Biology