Bartłomiej Tomiczek

This study examines how Class B J-Domain Proteins enhance Hsp70-mediated protein disaggregation through autoinhibition and EEVD motif interactions.

This paper investigates the evolutionary origin of class B J-domain proteins, showing they evolved from class A duplicates by losing their zinc finger domain, enabling new functions in amyloid aggregate regulation.

This study investigates how J-domain proteins induce conformational changes in Hsp70 to activate ATP hydrolysis through free energy simulations and network analysis.

The paper investigates the two-step mechanism of J-domain action in Hsp70 function, revealing how JDPs perturb Hsp70's intramolecular network and enable ATP hydrolysis through conserved and variable residues.

OMA standalone is a tool for orthology inference across public and custom genomes, enabling analysis of both existing and user-provided data.