Author

Jarosław Marszałek

University of GdańskORCID 0000-0002-6978-1189Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Bartłomiej TomiczekiD· 3 shared Jacek CzubiD· 3 shared Brenda A. SchilkeiD· 2 shared Elizabeth Anne CraigiD· 2 shared Łukasz NierzwickiiD· 2 shared Marcin PitekiD· 2 shared Milena StolarskaiD· 2 shared Agnieszka A. KlosowskaiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersEvolutionary Biology

Bartłomiej TomiczekORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Origin of Class B J-domain proteins involved in amyloid transactions

Przemyslaw Domanski, Milena Stolarska, Katarzyna Kalinowska, Dominik Purzycki, Brenda A. Schilke, Hubert Wyszkowski, Marcin Pitek, Aneta Szymańska, Katarzyna Bury, Jacek Czub, Agnieszka A. Klosowska, Elizabeth Anne Craig, Jarosław Marszałek, Bartłomiej Tomiczek

This paper investigates the evolutionary origin of class B J-domain proteins, showing they evolved from class A duplicates by losing their zinc finger domain, enabling new functions in amyloid aggregate regulation.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedEvolutionary Biology

Mechanism and energetics of JDP induced Hsp70's conformational transition towards catalytically active state

Michał Olewniczak, Marcin Pitek, Jacek Czub, Jarosław Marszałek, Łukasz Nierzwicki, Bartłomiej Tomiczek

This study investigates how J-domain proteins induce conformational changes in Hsp70 to activate ATP hydrolysis through free energy simulations and network analysis.

bioRxiv · May 22, 2025 · PreprintBiophysics

Two-step mechanism of J-domain action in driving Hsp70 function

Bartłomiej Tomiczek, Wojciech Delewski, Łukasz Nierzwicki, Milena Stolarska, Igor Grochowina, Brenda A. Schilke, Rafał Dutkiewicz, Marta A. Uzarska, Szymon J. Ciesielski, Jacek Czub, Elizabeth Anne Craig, Jarosław Marszałek

The paper investigates the two-step mechanism of J-domain action in Hsp70 function, revealing how JDPs perturb Hsp70's intramolecular network and enable ATP hydrolysis through conserved and variable residues.

PLoS Computational Biology · Jun 1, 2020Peer-reviewedMolecular Biology