Author

Wuhbet D. Abraham

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Darrell J. IrvineiD· 2 shared Alexandra NeeseriD· 1 shared Anna M. RomanoviD· 1 shared Austin Cozzone· 1 shared Beatriz Goncalves· 1 shared Benjamin James Cossette· 1 shared Bridget Li· 1 shared Byungji KimiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

Darrell J. IrvineORCID

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedAug 25, 2025

Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

Tomasz M. Grzywa, Alexandra Neeser, Ranjani Ramasubramanian…·Darrell J. Irvine

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

8 citations

mouseexperimental assay

BioengineeringbioRxivPreprintMar 9, 2025

Targeted suppression of type 1 interferon signaling during RNA delivery enhances vaccine-elicited immunity

Byungji Kim, Ryan Ramsey Hosn, Tanaka K. Remba…·Darrell J. Irvine

This study shows that co-delivering siRNA targeting IFNAR1 with RNA vaccines enhances antigen expression, immune cell infiltration, and antibody and T cell responses.

5 citations

mousebulk RNA-seq