Targeted suppression of type 1 interferon signaling during RNA delivery enhances vaccine-elicited immunity
Byungji Kim, Ryan Ramsey Hosn, Tanaka K. Remba, Jonathan Dye, Howard H. Mak, Jae Yun Jeong, Milton R. Cornwall-Brady, Wuhbet D. Abraham, Laura Maiorino, Mariane B. Melo, Bridget Li, Yuebao Zhang, Yizhou Dong, Darrell J. Irvine
This study shows that co-delivering siRNA targeting IFNAR1 with RNA vaccines enhances antigen expression, immune cell infiltration, and antibody and T cell responses.
bioRxiv · Mar 9, 2025 · PreprintBioengineering