Author

Y. H. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Approach:mechanistic / dynamical model· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

J. Lescar· 2 shared A. El Sahili· 1 shared B. C. Goh· 1 shared B. Chen· 1 shared B. D/O Shunmuganathan· 1 shared B. Wang· 1 shared C. F. Liu· 1 shared C.-I. Wang· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

J. Lescar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

M. Li, Y. Ren, Z. Q. Aw, B. Chen, Z. Yang, Y. Lei, L. Cheng, Q. Liang, J. Hong, Y. Yang, J. Chen, Y. H. Wong, S. Shan, S. Zhang, J. Ge, , L. Zhang

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

bioRxiv · Apr 12, 2022 · PreprintImmunology

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

N. K. Tulsian, P. V. Raghuvamsi, X. Qian, G. Yue, B. D/O Shunmuganathan, F. Samsudin, Y. H. Wong, L. Jianqing, K. Purushotorman, M. K. McQueen, B. Wang, J. Lescar, C.-I. Wang, G. Anand, P. J. Bond, P. A. MacAry

This study identifies site-specific allosteric effects in SARS-CoV-2 Spike protein induced by different neutralizing antibodies, revealing dynamic features that distinguish weak from strong neutralizers.

bioRxiv · Dec 27, 2021 · PreprintBiochemistry

Structural basis for substrate recognition, ligation and activation by a hyperactive Asn peptide ligase from Viola yedoensis

J. Lescar, S. Hu, A. El Sahili, S. Kishore, X. Hemu, C. F. Liu, J. P. Tam, B. C. Goh, Y. H. Wong, Z. Wang

The paper captures VyPAL2, a plant peptide ligase with a bound substrate, revealing the molecular basis for substrate recognition and ligation.

bioRxiv · Dec 9, 2021 · PreprintBiochemistry