Author

B. C. Goh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

J. Lescar· 3 shared A. El Sahili· 2 shared J. Lin· 2 shared A. E. Muruato· 1 shared A. E. Sahili· 1 shared A. Marquardt· 1 shared B. Colley· 1 shared B. K. Kalveram· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. Lescar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Z. Ku, X. Xie, J. Lin, P. Gao, A. E. Sahili, H. Su, Y. Liu, X. Ye, X. Li, X. Fan, B. C. Goh, W. Xiong, H. Boyd, A. E. Muruato, H. Deng, , Z. An

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

bioRxiv · Feb 1, 2022 · PreprintMicrobiology

Structural basis for substrate recognition, ligation and activation by a hyperactive Asn peptide ligase from Viola yedoensis

J. Lescar, S. Hu, A. El Sahili, S. Kishore, X. Hemu, C. F. Liu, J. P. Tam, B. C. Goh, Y. H. Wong, Z. Wang

The paper captures VyPAL2, a plant peptide ligase with a bound substrate, revealing the molecular basis for substrate recognition and ligation.

bioRxiv · Dec 9, 2021 · PreprintBiochemistry

All-Atom MD Simulations of the HBV Capsid Complexed with AT130 Reveal Secondary and Tertiary Structural Changes and Mechanisms of Allostery

C. Perez Segura, B. C. Goh, J. A. Hadden-Perilla

This study uses all-atom MD simulations to show AT130 stabilizes HBV capsid structure and reveals new conformational states and allostery mechanisms.

bioRxiv · Feb 8, 2021Biophysics

The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa

W.-H. Poh, J. Lin, B. Colley, N. Müller, B. C. Goh, D. Schleheck, A. El Sahili, A. Marquardt, Y. Liang, S. Kjelleberg, J. Lescar, S. A. Rice, J. Klebensberger

This study identifies the SiaABC threonine phosphorylation pathway as a regulator of biofilm formation in Pseudomonas aeruginosa in response to carbon availability and surfactant stress.

bioRxiv · Apr 16, 2020Microbiology

Characterization and establishment of a novel EBV strain simultaneously associated with nasopharyngeal carcinoma and B-cell lymphoma

F. Yu, N. Syn, Y. Lu, Q. Y. Chong, J. Lai, W. J. Tan, B. C. Goh, P. A. MacAry, L. Wang, K. S. Loh

The paper characterizes a novel EBV strain, Yu103, associated with both nasopharyngeal carcinoma and B-cell lymphoma, showing its dual tropism and unique genomic features.

bioRxiv · Mar 26, 2020Cancer Biology