X. Jia

This study develops a thermostable anti-EBOV IgY antibody that retains neutralizing activity for one year at 25°C and provides complete protection in a mouse model.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

This paper presents a high-resolution crystal structure of HIV-1 Nef interacting with AP2, revealing how Nef sequesters CD4 for degradation and identifying a dual-function pocket crucial for both MHC recruitment and CD4 binding.

This paper identifies an acidic cluster motif in SERINC5 that mediates resistance to HIV-1 Nef antagonism, showing its importance in Nef sensitivity without affecting intrinsic antiviral activity.

This study identifies two FDA-approved drugs, lacidipine and phenothrin, as Lassa virus entry inhibitors through high-throughput screening and mechanistic analysis.

The paper identifies that phosphoserine acidic cluster motifs in transmembrane proteins bind distinct basic regions on clathrin adaptor protein μ subunits, revealing potential for virus-specific inhibition.