Giant KASH proteins and ribosomes synergistically establish cytoplasmic biophysical properties in vivo
Xiangyi Ding, Hongyan Hao, Daniel Elnatan, Patrick Neo Alinaya, Shilpi Kalra, Abby Kaur, Sweta Kumari, Liam J. Holt, G. W. Gant Luxton, Daniel A. Starr
The paper identifies two conserved mechanisms controlling cytoplasmic macromolecular diffusion in C. elegans tissues, involving ribosome concentration and the giant KASH protein ANC-1.
bioRxiv · Jan 10, 2025 · PreprintBiophysics