The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks
Wei Song, Yichen Zhao, Annamaria Ruggiano, Christina Redfield, Joseph A. Newman, Xiaosheng Zhu, Marta García‐Flores, Abimael Cruz-Migoni, Rebecca Roddan, Anna Pérez‐Ràfols, Peter J. McHugh, P.R. Elliott, Kristijan Ramadan
This study identifies a ubiquitin-binding domain in SPRTN that enhances its proteolytic activity towards polyubiquitinated DNA-protein crosslinks.
Nucleic Acids Research · Jul 8, 2025Peer-reviewedBiochemistry