P.R. Elliott

DNA-induced conformational changes in SPRTN relieve its auto-inhibitory effect on protease activity

This study reveals how DNA-induced conformational changes in SPRTN relieve its auto-inhibitory effect on protease activity, enabling efficient DPC proteolysis.

M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic Stress

This study shows LUBAC activates AMPK and OTULIN restricts it, affecting metabolic responses to energy stress in cells, mice, and flies.

KDM7-mediated oxygen sensing reprograms chromatin to enhance hypoxia tolerance in the root

The paper shows that KDM7s act as oxygen sensors in Arabidopsis root tips, reprogramming chromatin to enhance hypoxia tolerance by increasing H3K4me3.

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

The paper identifies RNF114 as a specific reader of ubiquitinated ADP-ribose using a chemoproteomics approach and validates its interaction with the modified molecule.

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

This study identifies a ubiquitin-binding domain in SPRTN that enhances its proteolytic activity towards polyubiquitinated DNA-protein crosslinks.

obABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors

This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.