Sleep deprivation selectively down-regulates astrocytic 5-HT2B receptors and triggers depressive-like behaviors via stimulating P2X7 receptors
Maosheng Xia, Zexiong Li, Shuai Li, Shanshan Liang, Xiaowei Li, Beina Chen, Manman Zhang, Chengyi Dong, Alexei Verkhratsky, Dawei Guan, Baoman Li
This study shows chronic sleep deprivation reduces astrocytic 5-HT2B receptors via P2X7 receptors, leading to depressive-like behaviors through increased arachidonic acid and PGE2 release.
Neuroscience Bulletin · Jun 6, 2020Peer-reviewedNeuroscience