Author

Xiaoxiao Xu

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Genetics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alan B Wells· 1 shared Alexander F. A. KeszeiiD· 1 shared Anthony Edward LangiD· 1 shared Arye Nehorai· 1 shared David R O'Brien· 1 shared Ekaterina A. RogaevaiD· 1 shared Elnaz Khalili Samani· 1 shared Gábor Géza KovácsiD· 1 shared

Activity by Year

2015-2025 · peak 1/yr

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10 top collaborators · 12 mutual co-author links

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1 shared paperGenetics

Alan B Wells

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3 papers

Recent·Most cited

Lewy-MSA hybrid fold drives distinct neuronal a-synuclein pathology

Masahiro Enomoto, Iván Martínez-Valbuena, Shelley L. Forrest, Xiaoxiao Xu, Renato P. Munhoz, Jun Li, Ekaterina A. Rogaeva, Anthony Edward Lang, Gábor Géza Kovács

The paper identifies a Lewy-MSA hybrid fold of α-synuclein in atypical MSA, linking distinct filament structures to neuronal versus oligodendroglial pathologies.

Communications Biology · Jun 16, 2025Peer-reviewedPathology

Unveiling the Structural Proteome of an Alzheimer's Disease Rat Brain Model

Elnaz Khalili Samani, S. M. Naimul Hasan, Matthew Waas, Alexander F. A. Keszei, Xiaoxiao Xu, Mahtab Heydari, Mary Elizabeth Hill, JoAnne McLaurin, Thomas Kislinger, Mohammad T. Mazhab‐Jafari

This study uses cryo-EM and BaR to analyze protein complexes in an Alzheimer's rat brain model, revealing structural insights relevant to multiple diseases.

Structure · Nov 29, 2024Peer-reviewedBiochemistry

The anatomical distribution of genetic associations

Alan B Wells, Nathan Kopp, Xiaoxiao Xu, David R O'Brien, Wei Yang, Arye Nehorai, Tracy L. Adair-Kirk, Raphael Kopan, Joseph D Dougherty

The paper develops a framework to test the relationship between gene expression across the body and sets of candidate genes, applying it to GWA loci, immune traits, and selective pressure in human genes.

Nucleic Acids Research · Nov 19, 2015Peer-reviewedGenetics