Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids
Yanping Li, Xiaoxin Xie, Daqi Deng, Zhiyuan Sun, Zhaoan Huang, Yisen Tang, Liang Fang, Wei Chen, Qionghua Zhu
This study investigates how the order of early mutations affects tumor initiation in colorectal cancer using engineered murine organoids, finding that mutation order influences tumorigenic properties and immune interactions.
bioRxiv · Jun 3, 2026 · PreprintCancer Biology