Improve the Efficacy of B7-H3-Targeting Antibody-Drug Conjugate DS-7300a in TP53-deficient Tumors by Inducing Ferroptosis
Javier Leo, Feiyu Chen, Wei Shi, Xin Liang, Chenling Meng, Qianlin Gu, Yaman Albittar, Zhen Fan, Jie Zhang, Boyi Gan, Sangeeta Goswami, Kendra S. Carmon, Daniel E. Frigo, Ana M. Aparicio, Di Zhao
This study shows that TP53-deficient tumors resist DS-7300a therapy, but inducing ferroptosis can enhance its efficacy in these cancers.
bioRxiv · May 8, 2026 · PreprintCancer Biology