A discrete Connexin26+ neural crest lineage emerges in mid-life and mediates enhanced central brainstem responses to elevated CO2 levels for deep breathing.
Xintao Zhang, Jie Zhang, John M. J. Lapage, Alexander V. Gourine, Nicholas Dale, Georgy Koentges
The paper identifies a Cx26+ neural crest lineage that emerges in mid-life and mediates enhanced CO2 responses in the brainstem, impacting breathing and metabolism.
bioRxiv · Sep 21, 2026 · PreprintNeuroscience