Alexander V. Gourine

The paper identifies a Cx26+ neural crest lineage that emerges in mid-life and mediates enhanced CO2 responses in the brainstem, impacting breathing and metabolism.

This study shows that CO2 signalling is critical for neurovascular coupling in the somatosensory cortex, as disrupting CO2-sensitive vasodilation or HCO3-/CO2 transport abolishes the response to neuronal activity.

The paper shows astrocytes produce nitric oxide from nitrite via mitochondrial sulfite oxidase during hypoxia, modulating cerebral blood flow.

This study shows that astrocytes in the nucleus of the solitary tract modulate baroreflex sensitivity through calcium signaling and ATP release, influenced by 5-HT and glutamate.

The paper describes an electrochemical technique using carbon fiber electrodes to simultaneously record brain tissue PO2, pH, and extracellular field potentials in vivo.

This study uses MRI in a rat model to show impaired glymphatic flow in brain regions linked to cognitive deficits in chronic liver disease and minimal hepatic encephalopathy.