Xuan Zhang

Aging activates latent enhancers that can be reversed withexercise

This study identifies age-acquired enhancers in mouse hearts and shows that exercise can reverse their activation.

Ambient-Condition Visualization of Metalloenzyme Reactive Intermediates Enabled by the SHINERS Paradigm

This paper demonstrates the use of SHINERS to visualize reactive metalloenzyme intermediates under aqueous conditions, revealing coordination states and mechanisms in several enzymes.

Chromosome-scale genome of the woody oilseed crop sacha inchi elucidates the molecular basis of alpha-linolenic acid biosynthesis and triacylglycerol accumulation in seeds

This study presents a chromosome-scale genome of sacha inchi, revealing mechanisms of ALA biosynthesis and TAG accumulation through transcriptome analysis and gene expression patterns.

Sequence-based modeling of plant epigenomes reveals cell-type-specific cis-regulatory grammar

The paper introduces PEAgent, a deep-learning framework predicting single-cell chromatin accessibility from DNA sequence in plants, revealing cell-type-specific cis-regulatory patterns and their conservation.

Easy-Multiome enables joint profiling of gene expression and chromatin accessibility in single cells

Easy-Multiome enables joint profiling of gene expression and chromatin accessibility in plant single cells with high efficiency and minimal workflow changes.

FOXA1 preserves cell polarity and restrains lysosome biogenesis in non-small cell lung adenocarcinoma

This study shows FOXA1 maintains cell polarity and limits lysosome biogenesis in lung adenocarcinoma by regulating transcriptional circuits and interacting with TFE3.

Integrative Multi-cohort Transcriptomics and Network Pharmacology Analysis Reveals Key Network Nodes and Potential Drug Clues in PCOS Granulosa Cells

The paper identifies key genes and potential drugs for PCOS by integrating transcriptomics and network pharmacology across multiple cohorts.

Differential Impact of Multiple Sensory Deprivation on Spatial-coding Cells in Medial Entorhinal Cortex

This study shows that tactile and visual inputs differently affect spatial coding in the MEC, with tactile cues compensating for visual loss in some cell types.