Non-enzymatic RNA Glycation is a Metabolic Sensor of Cellular Stress
Anna Knörlein, Kaila Nishikawa, Naoya Kitamura, Reena Kumari, Shino Murakami, Ankita Shrivastava, Malina Doynova, Nicolae Ciobu, Nicole S. Walker, Xiaohan Mei, Abdul Vehab Dozic, Jahan A. Rahman, Yang Xiao, Chiara Evans, Xuejing Yang, , Yael David
This study identifies mRNA glycation by methylglyoxal as a metabolic stress sensor, showing impaired translation and beta-cell dysfunction, which is mitigated by metformin.
bioRxiv · May 19, 2026 · PreprintMolecular Biology