HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel disease
Xuewei Qi, Alessandra Granata, Tom Van Agtmael, Sanjay Sinha, M. Zameel Cader, Hugh Stephen Markus, Stuart McRae Allan, Karen J. Horsburgh, Tao Wang
This study identifies HTRA1 deficiency in COL4A1 mutant astrocytes as a mechanism underlying BBB dysfunction in cerebral small vessel disease.
bioRxiv · Jun 16, 2026 · PreprintNeuroscience