Sanjay Sinha

This study evaluates densified collagen tubes as interposition grafts in rat abdominal aorta, showing patent grafts for 17 weeks with neointima formation and re-endothelialization but late thrombosis.

This study identifies HTRA1 deficiency in COL4A1 mutant astrocytes as a mechanism underlying BBB dysfunction in cerebral small vessel disease.

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

The paper develops a chemically defined, xeno-free hydrogel system that supports hPSC differentiation into multiple tissue types and improves hepatocyte retention in vivo.

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

This study develops a multi-omic reference of human cardiac development and identifies disruptions in Trisomy 21 hearts.

The paper creates a high-resolution human developing heart atlas using single-cell and spatial transcriptomics, identifies new cell types, and benchmarks in vitro models.

This study shows that modified mRNA encoding Myc and Cyclin T1 can induce cardiomyocyte proliferation and improve cardiac function after myocardial injury in mice.

This study shows RBPMS induces contractile splicing patterns and alters phenotypic behavior in human embryonic stem cell-derived vascular smooth muscle cells.

This study investigates how cell cycle regulators influence mesoderm specification in human pluripotent stem cells, finding that CDKs and pRb phosphorylation are context-dependent for efficient mesoderm formation.

The paper identifies RBPMS as a master splicing regulator in vascular smooth muscle cells by analyzing its proximity to super-enhancers and its role in alternative splicing during phenotypic switching.