Karen J. Horsburgh

This study identifies HTRA1 deficiency in COL4A1 mutant astrocytes as a mechanism underlying BBB dysfunction in cerebral small vessel disease.

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

This study examines how stroke alters myeloid cell composition and phenotypes in the brain, linking changes to cell origin, spatial organization, and brain connectivity.

This study shows that bilateral common carotid stenosis impairs glymphatic function and vascular pulsation in mice, contributing to cognitive decline in vascular cognitive impairment.