Author

Alessandra Granata

University of CambridgeORCID 0000-0001-5051-8201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Hugh Stephen MarkusiD· 2 shared Karen J. HorsburghiD· 2 shared M. Zameel CaderiD· 2 shared Sanjay SinhaiD· 2 shared Stuart McRae AllaniD· 2 shared Tao WangiD· 2 shared Tom Van AgtmaeliD· 2 shared Alexandra V. PokhilkoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Hugh Stephen MarkusORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 16, 2026

HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel disease

Xuewei Qi, Alessandra Granata, Tom Van Agtmael…·Tao Wang

This study identifies HTRA1 deficiency in COL4A1 mutant astrocytes as a mechanism underlying BBB dysfunction in cerebral small vessel disease.

DOI 10.64898/2026.05.12.724691

humanbulk RNA-seq

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NeurosciencebioRxivPreprintApr 4, 2025

Cerebral small vessel disease due to Col4a1 mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding.

Gaia Brezzo, Alexandra V. Pokhilko, Jon Moss…·Karen J. Horsburgh

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

DOI 10.1101/2025.04.04.647207

mouseexperimental assay

𝕏 PostBluesky