Author

Xun Wang

Children's Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Alpaslan TasdoganiD· 1 shared Ashley Rowe· 1 shared Ashley SolmonsoniD· 1 shared Aundrea K. WestfalliD· 1 shared Brandon FaubertiD· 1 shared Bushra AfrozeiD· 1 shared Chen LiiD· 1 shared Dong Duan· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperGenetics

Alpaslan TasdoganORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

Wen Gu, Xun Wang, Ashley Solmonson, Ling Cai, Yi Xiao, Alpaslan Tasdogan, Jordan Franklin, Yuannyu Zhang, Hua Zhang, Aundrea K. Westfall, Ashley Rowe, H S Trivedi, Brandon Faubert, Zheng Wu, Jessica Sudderth, , Ralph J. DeBerardinis

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

Journal of Clinical Investigation · Mar 17, 2026Peer-reviewedGenetics

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

Yu Lei, Yajie Wang, Yuanchen Liu, Xiaomin Xing, Chen Li, Xun Wang, Jialu Shi, Wentai Ma, Jiayan Li, Yanjia Chen, Rui Qiao, Xiaoyu Zhao, Shilei Tian, Ming Gao, Shuhua Wen, , Pengfei Wang

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from individuals exposed only to ancestral SARS-CoV-2.

Communications Biology · Mar 6, 2025Peer-reviewedMicrobiology

Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

Xu Zheng, Shi Yu, Yanqiu Zhou, Kuai Yu, Yuhui Gao, Mengdan Chen, Dong Duan, Yunyi Li, Xiaoxian Cui, Jiabin Mou, Yuying Yang, Xun Wang, Min Chen, Yaming Jiu, Jincun Zhao, Guangxun Meng

The paper identifies IL-1β as a factor that inhibits SARS-CoV-2-induced cell-cell fusion by promoting actin bundles, thereby restricting viral transmission.

bioRxiv · May 16, 2024Immunology