Author

Hua Zhang

University of Wisconsin–MadisonORCID 0000-0003-2875-7243Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hua Zhang4 papers · Shaanxi Normal University

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Amy HuiD· 2 shared Ashley SolmonsoniD· 2 shared Lang DingiD· 2 shared Meng Carla WangiD· 2 shared Paul W. TillbergiD· 2 shared Alejandro Aguilera-CastrejoniD· 1 shared Alessandro ValenteiD· 1 shared Alpaslan TasdoganiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersDevelopmental Biology

Amy HuORCID

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3 papers

Recent·Most cited

Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs

Dmitry Lokshtanov, Shihong Max Gao, Weizhi Xu, Avraham Kosman, Francesco Roncato, Nancy De La Cruz, Nawal A. Khan, Andrea Woods, Ian J. Campbell, Andrew Woehler, Christina P. Christoforou, Lang Ding, Amy Hu, Monique Copeland, Lihua Wang, , Alejandro Aguilera-Castrejon

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

bioRxiv · Mar 18, 2026 · PreprintDevelopmental Biology

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

Wen Gu, Xun Wang, Ashley Solmonson, Ling Cai, Yi Xiao, Alpaslan Tasdogan, Jordan Franklin, Yuannyu Zhang, Hua Zhang, Aundrea K. Westfall, Ashley Rowe, H S Trivedi, Brandon Faubert, Zheng Wu, Jessica Sudderth, , Ralph J. DeBerardinis

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

Journal of Clinical Investigation · Mar 17, 2026Peer-reviewedGenetics

TEMI: Tissue Expansion Mass Spectrometry Imaging

Hua Zhang, Lang Ding, Amy Hu, Xudong Shi, Penghsuan Huang, Haiyan Lu, Paul W. Tillberg, Meng Carla Wang, Lingjun Li

TEMI maps biomolecule distributions in tissues at single-cell resolution, revealing metabolic heterogeneity in tumors.

Nature Methods · Apr 22, 2025Peer-reviewedMolecular Biology