Yuannyu Zhang

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

Carbohydrate adaptation drives liver-brain axis maturation

The paper shows that LACTB2 in the liver regulates mitochondrial maturation to coordinate carbohydrate metabolism with brain development in mice.

Epo-IGF1R crosstalk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm

The paper identifies a stress-specific erythroid progenitor population that links regenerative erythropoiesis to pathogenic erythrocytosis through Epo-IGF1R crosstalk.

Interrogation of Enhancer Function by Enhanced CRISPR Epigenetic Editing

This paper introduces enhanced CRISPR epigenetic editing systems to analyze enhancer function in vivo, showing improved modulation of gene transcription with minimal off-target effects.

Dissecting super-enhancer hierarchy based on chromatin interactions

The paper identifies hub enhancers within super-enhancers using Hi-C and ChIP-seq data, showing their role in gene activation and chromatin structure.