Author

Jordan Franklin

Children's Medical CenterORCID 0000-0002-0992-6673Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1

Frequent Co-Authors

Bushra AfrozeiD· 2 shared Feng CaiiD· 2 shared Jessica SudderthiD· 2 shared Lauren G. ZachariasiD· 2 shared Ling CaiiD· 2 shared Ralph J. DeBerardinisiD· 2 shared Wen GuiD· 2 shared Zheng WuiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersGenetics

Bushra AfrozeORCID

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2 papers

Recent·Most cited

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

Wen Gu, Xun Wang, Ashley Solmonson, Ling Cai, Yi Xiao, Alpaslan Tasdogan, Jordan Franklin, Yuannyu Zhang, Hua Zhang, Aundrea K. Westfall, Ashley Rowe, H S Trivedi, Brandon Faubert, Zheng Wu, Jessica Sudderth, , Ralph J. DeBerardinis

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

Journal of Clinical Investigation · Mar 17, 2026Peer-reviewedGenetics

An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism

Ling Cai, Hieu Vu, Wen Gu, Hongli Chen, Jordan Franklin, Lea Abou Haidar, Zheng Wu, Chunxiao Pan, Feng Cai, Phong Nguyen, Bookyung Ko, Chendong Yang, Lauren G. Zacharias, Jessica Sudderth, Sarah Montgomery, , Ralph J. DeBerardinis

The paper introduces a web application for exploring metabolomics data from plasma and fibroblasts of patients with inborn errors of metabolism, enabling analysis of metabolic deviations and relationships.

bioRxiv · Dec 11, 2023 · PreprintBioinformatics