Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD
Teng Han, Zhen Sun, Matthew Lange, Y Zoe Cho, Patrick D. McGillivray, Maren Büttner, Nathaniel R. Kastan, Subhiksha Nandakumar, HuiYong Zhao, Eralda Salataj, Sanyukta Oak, Linda E. Fong, Wenfei Kang, Ning Fan, Francesca Mazzoni, , Charles L. Sawyers
Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.
bioRxiv · Aug 23, 2026 · PreprintCancer Biology✦ In-depth digest