Cancer BiologybioRxivPreprint
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Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD
Teng Han, Zhen Sun, Matthew Lange…·Charles L. Sawyers
Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.