Author

Y. Akimov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

D. Bulanova· 2 shared K. Wennerberg· 2 shared T. Aittokallio· 2 shared A. Bugai· 1 shared A. F. Arutyunyan· 1 shared A. Ianevski· 1 shared A. L. Zhuze· 1 shared A. Waage· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

D. Bulanova

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing drugs in RB1-deficient ovarian and breast cancer cells

D. Bulanova, Y. Akimov, W. Senkowski, J. Oikkonen, L. Gall-Mas, S. Timonen, M. Elmadani, J. Hynninen, S. Hautaniemi, T. Aittokallio, K. Wennerberg

This study identifies CK2 inhibition as a sensitizing strategy for RB1-deficient ovarian and breast cancer cells to replication-perturbing drugs, showing enhanced efficacy when combined with existing therapies.

bioRxiv · Nov 14, 2022 · PreprintCancer Biology

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

A. Ianevski, E. Kulesskiy, K. Krpina, G. Lou, Y. Aman, A. Bugai, K. Aasumets, Y. Akimov, D. Bulanova, K. Gildemann, A. F. Arutyunyan, O. Y. Susova, A. L. Zhuze, P. Ji, W. Wang, , D. E. Kainov

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

bioRxiv · Jan 13, 2020Cancer Biology

DNA barcode-guided lentiviral CRISPRa tool to trace and isolate individual clonal lineages in heterogeneous cancer cell populations

Y. Akimov, D. R. Bulanova, M. Abyzova, K. Wennerberg, T. Aittokallio

This paper introduces a DNA barcode-guided CRISPRa tool for tracing and isolating individual clonal lineages in cancer cell populations, enabling unbiased analysis of subclonal evolution.

bioRxiv · Apr 29, 2019 · PreprintCancer Biology