Author

D. E. Kainov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

M. Bjoras· 8 shared A. Ianevski· 7 shared E. Zusinaite· 7 shared V. Oksenych· 7 shared H. Lysvand· 6 shared R. Yao· 5 shared T. Tenson· 5 shared M. H. Fenstad· 4 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

8 shared papersMicrobiology

M. Bjoras

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

A. Ianevski, R. Yao, R. M. Simonsen, V. Myhre, E. Ravlo, G. D. Kaynova, E. Zusinaite, J. M. White, Q. Pan, S. J. Polyak, V. Oksenych, M. P. Windisch, E. Lastauskiene, A. Vitkauskiene, A. Matukevicius, , D. E. Kainov

The paper develops scoring systems to predict novel broad-spectrum antivirals and combinations, aiming to improve preparedness for future viral outbreaks.

bioRxiv · Jan 15, 2022 · PreprintMicrobiology

Active components of commonly prescribed medicines affect influenza A virus-host cell interaction: a pilot study

A. Ianevski, R. Yao, E. Zusinaite, H. Lysvand, V. Oksenych, T. Tenson, M. Bjoras, D. E. Kainov

This study examines how active components of commonly prescribed medicines affect influenza A virus-host cell interactions both in silico and in vitro.

bioRxiv · Jul 11, 2021Pharmacology & Toxicology

Nafamostat-interferon-alpha combination suppresses SARS-CoV-2 infection by targeting cooperatively host TMPRSS2 in vitro and in vivo

A. Ianevski, R. Yo, H. Lysvand, G. Grodeland, N. Legrand, V. Oksenych, E. Zusinaite, T. Tenson, M. Bjoras, D. E. Kainov

This study combines nafamostat and interferon-alpha to suppress SARS-CoV-2 infection by targeting TMPRSS2 in vitro and in vivo.

bioRxiv · Jun 16, 2021Microbiology

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

A. Ianevski, R. Yao, E. Zusinaite, L. S. Lello, S. Wang, E. Jo, J. Yang, E. Ravlo, W. Wang, H. Lysvand, K. Loseth, V. Oksenych, T. Tenson, M. P. Windisch, M. Poranen, , D. E. Kainov

This study shows that IFNa-based combinations effectively inhibit SARS-CoV-2 infection in vitro and in vivo, with synergistic effects against other viruses.

bioRxiv · Jan 5, 2021 · PreprintMicrobiology

Identification of novel antiviral drug combinations in vitro and tracking their development

A. Ianevski, R. Yao, S. Biza, E. Zusinaite, A. Mannik, G. Kivi, A. Planken, K. Kurg, E.-M. Tombak, M. Ustav, N. Shtaida, E. Kulesskiy, E. Jo, J. Yang, H. Lysvand, , D. E. Kainov

This study identifies novel synergistic antiviral drug combinations effective against SARS-CoV-2, echovirus 1, HCV, and HIV-1 in vitro and provides an online resource for their developmental status.

bioRxiv · Sep 17, 2020 · PreprintMicrobiology

Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with an endemic human CoV

J. T. Ladner, S. N. Henson, A. S. Boyle, A. L. Engelbrektson, Z. W. Fink, F. Rahee, J. D'ambrozio, K. E. Schaecher, M. Stone, W. Dong, S. Dadwal, J. Yu, M. A. Caligiuri, P. Cieplak, M. Bjoras, , J. A. Altin

This study uses PepSeq to map SARS-CoV-2 antibody epitopes and identifies cross-reactivity with hCoV-OC43.

bioRxiv · Jul 27, 2020Immunology

Potential antiviral options against SARS-CoV-2 infection

A. Ianevski, R. Yao, M. H. Fenstad, S. Biza, E. Zusinaite, H. Lysvand, K. Loeseth, V. M. Lamndsem, J. F. Malmring, V. Oksenych, S. E. Erlandsen, P. A. Aas, L. Hagen, C. H. Pettersen, J. E. Afset, , D. E. Kainov

The paper identifies potent convalescent sera and broad-spectrum antivirals effective against SARS-CoV-2 using a neutralization assay and cell culture screening.

bioRxiv · May 12, 2020Microbiology

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

A. Ianevski, E. Kulesskiy, K. Krpina, G. Lou, Y. Aman, A. Bugai, K. Aasumets, Y. Akimov, D. Bulanova, K. Gildemann, A. F. Arutyunyan, O. Y. Susova, A. L. Zhuze, P. Ji, W. Wang, , D. E. Kainov

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

bioRxiv · Jan 13, 2020Cancer Biology