Enhancement of Target Specificity of CRISPR-Cas12a by Using a Chimeric DNA-RNA Guide
H. Kim, W.-j. Lee, S.-H. Kang, J. K. Hur, H. Lee, W. Song, K.-S. Lim, Y.-H. Park, B.-S. Song, Y. B. Jin, B.-H. Jun, D.-S. Lee, S.-U. Kim, S. H. Lee
This study enhances CRISPR-Cas12a specificity by using a chimeric DNA-RNA guide, reducing off-target mutations in genome editing.
bioRxiv · Feb 4, 2020Biochemistry