Author

Y. Dunkel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

N. Aznar· 4 shared P. Ghosh· 4 shared J. Ear· 3 shared N. Sun· 2 shared A. Goel· 1 shared A. Reid· 1 shared B. Lim· 1 shared D. Sahoo· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCancer Biology

N. Aznar

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Malignant Melanoma

Y. Dunkel, A. Reid, J. Ear, N. Aznar, M. Millward, E. Gray, R. Pearce, M. Ziman, P. Ghosh

The paper shows that Daple transcript isoforms V1 and V2 in peripheral blood predict melanoma prognosis, with V2 improving survival and V1 worsening it.

bioRxiv · Jun 17, 2018Cancer Biology

Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors

Y. Dunkel, J. Ear, Y. Mittal, B. Lim, L. Liu, M. Holda, U. Nitsche, J. Barbazan, A. Goel, K.-P. Janssen, N. Aznar, P. Ghosh

The paper identifies two Daple/CCDC88C isoforms, showing they cooperatively suppress tumor growth but only the full-length isoform triggers EMT and invasion, with aspirin affecting their expression.

bioRxiv · May 2, 2018Cancer Biology

Akt/PKB enhances non-canonical Wnt signals by compartmentalizing β-Catenin

N. Aznar, N. Sun, Y. Dunkel, J. Ear, M. Buschman, P. Ghosh

This study shows that Akt/PKB enhances non-canonical Wnt signals by phosphorylating Daple, which compartmentalizes β-catenin to cell-cell contact sites, suppressing colony growth.

bioRxiv · Jun 13, 2017Cell Biology

Convergence of Wnt, Growth Factor and Trimeric G protein signals on Daple

N. Aznar, Y. Dunkel, N. Sun, K. Satterfield, F. He, I. Lopez-Sanchez, M. Ghassemian, D. Sahoo, I. Kufareva, P. Ghosh

This study identifies Daple as a convergence point for Wnt, growth factor, and G-protein signaling in cancer, showing its role in tumor progression and poor prognosis in colorectal cancer.

bioRxiv · Jun 12, 2017Cancer Biology