K.-P. Janssen

Endoplasmic reticulum stress signaling actively contributes to therapy resistance in colorectal cancer

This study investigates how ER stress signaling contributes to therapy resistance in colorectal cancer by analyzing genomic alterations and testing therapeutic responses in cell lines and organoids.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Gut microbial disruption in critically ill patients with COVID-19 associated pulmonary aspergillosis

This study investigates the gut and bronchial microbiota in critically ill COVID-19 patients with and without CAPA, finding reduced gut diversity and increased Staphylococcus epidermidis in CAPA patients.

B/T cell crosstalk and aberrant inflammatory IgG exacerbate autoimmune intestinal inflammation

This study identifies B cell-driven inflammatory mechanisms, including aberrant IgG production and CD86-mediated T cell activation, as contributors to exacerbated intestinal inflammation in IBD.

The gut microbiota promotes liver regeneration through hepatic membrane phospholipid synthesis

This study shows that gut microbiota supports liver regeneration by promoting hepatic phospholipid synthesis, with antibiotic-induced dysbiosis impairing this process.

Gut Bacterial Dysbiosis and Instability is Associated with the Onset of Complications and Mortality in COVID-19

The paper analyzes gut and oral microbiota in COVID-19 patients to show associations between microbial dysbiosis, complications, and mortality.

Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors

The paper identifies two Daple/CCDC88C isoforms, showing they cooperatively suppress tumor growth but only the full-length isoform triggers EMT and invasion, with aspirin affecting their expression.