Author

Y. Isobe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

D. K. Nomura· 2 shared T. J. Maimone· 2 shared B. P. Belcher· 1 shared B. So· 1 shared B. Tong· 1 shared E. Ho· 1 shared H. Bui· 1 shared J. A. Tallarico· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

D. K. Nomura

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Author profile →

3 papers

Recent·Most cited

Liquid-liquid extraction of lipidated peptides for direct identification of lipidation sites

K. Tsumagari, Y. Isobe, Y. Ishihama, J. Seita, M. Arita, K. Imami

This paper introduces a proteomic method to identify endogenous lipidation sites using liquid-liquid extraction and mass spectrometry, finding 90 sites in HeLa cells and tissue-specific profiles in mice.

bioRxiv · May 25, 2023 · PreprintBiochemistry

Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3

B. P. Belcher, P. A. Machicao, B. Tong, E. Ho, J. Friedli, B. So, H. Bui, Y. Isobe, T. J. Maimone, D. K. Nomura

This study identifies dankastatin B as a covalent inhibitor of VDAC3 in breast cancer cells, revealing its mechanism of action through chemoproteomic profiling.

bioRxiv · Feb 11, 2023 · PreprintBiochemistry

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity

Y. Isobe, M. Okumura, R. White, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, T. J. Maimone, D. K. Nomura

The paper identifies manumycin polyketides as molecular glues that bind UBR7 and P53, impairing breast cancer pathogenicity through p53 activation and cell death.

bioRxiv · Oct 22, 2019 · PreprintBiochemistry