Author

B. Tong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. Zheng· 2 shared D. K. Nomura· 2 shared F. Tian· 2 shared P. Zheng· 2 shared T. J. Maimone· 2 shared X. Dong· 2 shared A. Tutter· 1 shared B. K. Hua· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiophysics

B. Zheng

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Rational screening for cooperativity in small-molecule inducers of protein-protein associations

S. Liu, B. Tong, J. W. Mason, J. M. Ostrem, A. Tutter, B. K. Hua, S. A. Tang, S. Bonazzi, K. Briner, F. Berst, F. J. Zecri, S. L. Schreiber

The paper introduces a binding-based screen to identify cooperative small-molecule inducers of protein-protein interactions, identifying a compound with high cooperativity comparable to classical molecular glues.

bioRxiv · May 22, 2023Biophysics

Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3

B. P. Belcher, P. A. Machicao, B. Tong, E. Ho, J. Friedli, B. So, H. Bui, Y. Isobe, T. J. Maimone, D. K. Nomura

This study identifies dankastatin B as a covalent inhibitor of VDAC3 in breast cancer cells, revealing its mechanism of action through chemoproteomic profiling.

bioRxiv · Feb 11, 2023 · PreprintBiochemistry

S373P Mutation Stabilizes the Receptor-binding Domain of Spike Protein in Omicron and Promotes Binding

B. Zheng, Y. Xiao, B. Tong, Y. Mao, R. Ge, F. Tian, X. Dong, P. Zheng

The paper investigates the effect of the S373P mutation on the stability and binding ability of the Omicron spike protein's RBD using AFM-SMFS and molecular dynamics simulations.

bioRxiv · Jun 22, 2022Biophysics

Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

F. Tian, B. Tong, L. Sun, S. Shi, B. Zheng, Z. Wang, X. Dong, P. Zheng

This study investigates how the N501Y mutation in the SARS-CoV-2 spike protein's RBD enhances its binding to ACE2, contributing to increased transmissibility of variants.

eLife · Aug 20, 2021Peer-reviewedBiophysics

A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

B. Tong, J. N. Spradlin, L. F. T. Novaes, E. Zhang, X. Hu, M. Moeller, S. M. Brittain, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, T. J. Maimone, D. K. Nomura

This paper develops a PROTAC molecule, BT1, that selectively degrades BCR-ABL over c-ABL in leukemia cells using nimbolide as an E3 ligase recruiter, showing additional anti-proliferative effects.

bioRxiv · Apr 2, 2020Biochemistry

Integration of gut microbiome, host biomarkers, and urine metabolome data reveals networks of interactions associated with distinct clinical phenotypes

R.-J. Li, Z.-Y. Jie, Q. Feng, R.-L. Fang, F. Li, Y. Gao, H.-H. Xia, H.-Z. Zhong, B. Tong, J.-Y. Xu, L. Madsen, C.-L. Liu, Z.-G. Xu, J. Wang, H.-M. Yang, , K.-L. He

bioRxiv · Jan 2, 2019Microbiology