Y. Kakinuma

Transcriptome analyses of mouse cardiac myocytes and non-cardiomyocytes: postmitotic vs. proliferative cells

This study compares gene expression in postmitotic cardiac myocytes and proliferative non-cardiomyocytes from young and aged mice, identifying age-related changes in mitochondrial genes and snoRNAs.

Positive feedback regulation of Pparγ1sv and Pparγ2 during adipogenesis in 3T3-L1 cells

The paper identifies PPARγ-binding sites in the Pparγ gene locus and proposes positive feedback regulation of Pparγ1sv and Pparγ2 during adipogenesis in 3T3-L1 cells.

Temporal inhibition of electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts

The paper shows that inhibiting mitochondrial respiration with antimycin A reduces stress-induced senescence in human fibroblasts by improving proteostasis.

Elevated blood pressure in high fat diet-exposed low birth weight rat offspring is most likely caused by elevated glucocorticoid levels

This study shows that high-fat diet exposure increases blood pressure in low birth weight rats through elevated glucocorticoid levels, suggesting a therapeutic target for hypertension in LBW individuals.

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblasts

This study shows that proteostasis disruption in human fibroblasts leads to mitochondrial dysfunction and biogenesis, contributing to cellular senescence through ROS accumulation and impaired antioxidant defenses.

Epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells

The paper investigates the epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells, finding changes in histone modifications but not DNA methylation.