Y. Takenaka

Transcriptome analyses of mouse cardiac myocytes and non-cardiomyocytes: postmitotic vs. proliferative cells

This study compares gene expression in postmitotic cardiac myocytes and proliferative non-cardiomyocytes from young and aged mice, identifying age-related changes in mitochondrial genes and snoRNAs.

Positive feedback regulation of Pparγ1sv and Pparγ2 during adipogenesis in 3T3-L1 cells

The paper identifies PPARγ-binding sites in the Pparγ gene locus and proposes positive feedback regulation of Pparγ1sv and Pparγ2 during adipogenesis in 3T3-L1 cells.

Discovery of the apiosyltransferase, celery UGT94AX1 that catalyzes the biosynthesis of a flavone glycoside, apiin

This paper identifies celery UGT94AX1 as the apiosyltransferase responsible for apiin biosynthesis and characterizes its substrate specificity and key residues.

Temporal inhibition of electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts

The paper shows that inhibiting mitochondrial respiration with antimycin A reduces stress-induced senescence in human fibroblasts by improving proteostasis.

Identification of lactic acid bacteria with reduced inflammatory and enhanced protective properties against influenza virus

This study identifies a lactic acid bacteria strain, D279, that shows strong anti-influenza properties without inducing inflammation.

NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblasts

This study shows that proteostasis disruption in human fibroblasts leads to mitochondrial dysfunction and biogenesis, contributing to cellular senescence through ROS accumulation and impaired antioxidant defenses.

Epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells

The paper investigates the epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells, finding changes in histone modifications but not DNA methylation.

Collaborative environmental DNA sampling from petal surfaces of flowering cherry Cerasus ×- yedoensis 'Somei-yoshino' across the Japanese archipelago

The paper collects and analyzes environmental DNA from petal surfaces of cherry trees across Japan, showing rapid DNA attachment and the presence of other plant DNA, supporting the use of petals for studying environmental DNA dynamics.