T. Nakano

Brassinosteroids function as the plant male and female reproductive hormone coordinating gene expression.

This study shows that brassinosteroids (BRs) function as reproductive hormones in Arabidopsis, regulating gene expression in both male and female reproductive tissues during fertilization.

Kaposis sarcoma-associated herpesvirus ORF67.5 functions as a component of the terminase complex

This study identifies ORF67.5 as a critical component of the KSHV terminase complex, essential for TR cleavage, capsid formation, and virus production.

The contribution of Kaposis sarcoma-associated herpesvirus ORF7 and its zinc-finger motif to viral genome cleavage and capsid formation

This study investigates the role of KSHV ORF7 and its zinc-finger motif in viral genome cleavage and capsid formation, revealing that ORF7 acts after ORF17 and is essential for proper capsid assembly and virion production.

NeoRdRp: A comprehensive dataset for identifying RNA-dependent RNA polymerase of various RNA viruses from metatranscriptomic data

The paper introduces NeoRdRp, a dataset of RNA-dependent RNA polymerase (RdRp) HMM profiles for identifying RNA viruses from metatranscriptomic data, showing improved detection compared to existing methods.

Stress-dependent cell stiffening by tardigrade tolerance proteins through reversible formation of cytoskeleton-like filamentous network and gel-transition

This study identifies CAHS proteins as stress-dependent cytoskeletal-like proteins that form reversible filaments and gels to enhance cell stiffness and dehydration resistance in tardigrades.

Molecular phylogeny of fucoxanthin-chlorophyll a/c proteins from Chaetoceros gracilis and Lhcq/Lhcf diversity

The paper identifies and classifies 46 FCPs in C. gracilis into five subfamilies, revealing insights into light-harvesting system diversification in red algae.

Variation and process of life history evolution in insular dwarfism as revealed by a natural experiment

The paper investigates life history evolution in insular dwarfism using deer populations, finding slower growth and delayed maturity in more isolated populations.

Screening of candidate host cell membrane proteins involved in SARS-CoV-2 entry

The paper identifies host cell membrane proteins that co-localize with SARS-CoV-2 spike proteins and show enhanced viral infectivity, suggesting potential roles in viral entry.

Bimolecule detection for Extracellular Vesicle Screening

The paper introduces a novel BiEV method to detect specific bimolecular surface antigens on extracellular vesicles for cancer screening, identifying CHL1-SLC4A1 and CHL1-caspase 14 as potential biomarkers in mouse and human samples.

NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblasts

This study shows that proteostasis disruption in human fibroblasts leads to mitochondrial dysfunction and biogenesis, contributing to cellular senescence through ROS accumulation and impaired antioxidant defenses.

Epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells

The paper investigates the epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells, finding changes in histone modifications but not DNA methylation.

Micro- and nanostructural characteristics of rat masseter muscle entheses -Characteristics of masseter muscle entheses-

This study examines micro- and nanostructural characteristics of rat masseter muscle entheses, showing alignment of bone apatite crystallites and collagen fibers related to mechanical loading.

Proximity proteomics identifies cancer cell membrane cis-molecular complex as a potential cancer target

The paper identifies cancer cell membrane cis-molecular complexes (BiCATs) as potential targets using proximity proteomics and shows their utility in combination drug strategies.