T. Nemoto

Body temperature regulates glucose metabolism and torpid

This study shows that body temperature, not ambient temperature, strongly regulates glucose metabolism and behavior in QIH mice, with hypometabolism being secondary to hypothermia.

Actin dynamics switches two distinct modes of endosomal fusion in yolk sac visceral endoderm cells

Autophagosome development and chloroplast segmentation occur synchronously for piecemeal degradation of chloroplasts

The paper shows that autophagosome development and chloroplast segmentation occur together during chloroplast degradation in sugar-starved leaves.

Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex

This study shows that tight junction membrane proteins regulate the mechanical resistance of apical junctions in epithelial cells by maintaining ZO-1 molecule organization.

Signal Improved ultra-Fast Light-sheet Microscope (SIFT) for large tissue imaging

The paper introduces an improved light-sheet microscope that increases imaging speed and signal strength for large tissue samples.

Complete loss of RelA and SpoT homologs in Arabidopsis reveals the importance of the plastidial stringent response in the interplay between chloroplast metabolism and plant defense response

This study shows that loss of plastid ppGpp synthases/hydrolases in Arabidopsis leads to reduced ppGpp levels, leaf chlorosis, and enhanced defense gene expression under nitrogen starvation.

Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction

The paper describes a two-step method using charged hydrogels and neural stem cell injection to promote brain tissue reconstruction after traumatic injury.

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi contact sites

The paper shows SCAP facilitates CARTS biogenesis at ER-Golgi contact sites by regulating cholesterol and PI4P exchange under cholesterol-fed conditions.

Elevated blood pressure in high fat diet-exposed low birth weight rat offspring is most likely caused by elevated glucocorticoid levels

This study shows that high-fat diet exposure increases blood pressure in low birth weight rats through elevated glucocorticoid levels, suggesting a therapeutic target for hypertension in LBW individuals.