Author

M. Hirasaki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

I. Inoue· 3 shared Y. Takenaka· 3 shared K. Uranishi· 2 shared M. Ikeda· 2 shared Y. Kakinuma· 2 shared A. Okuda· 1 shared A. Shimada· 1 shared A. Suzuki· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersPhysiology

I. Inoue

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transcriptome analyses of mouse cardiac myocytes and non-cardiomyocytes: postmitotic vs. proliferative cells

Y. Takenaka, M. Hirasaki, I. Inoue, M. Ikeda, H. Ohata, Y. Kakinuma

This study compares gene expression in postmitotic cardiac myocytes and proliferative non-cardiomyocytes from young and aged mice, identifying age-related changes in mitochondrial genes and snoRNAs.

bioRxiv · Aug 20, 2023 · PreprintPhysiology

PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer

Y. Mihara, M. Hirasaki, Y. Horita, T. Fujino, H. Fukushima, Y. Kamakurab, K. Uranishi, Y. Hirano, S. Ryozawa, M. Yasuda, Y. Makino, S. Shibasaki, T. Hamaguchi

The paper identifies two single-nucleotide variants in the PTEN-induced kinase 1 gene associated with lower recurrence rates in colorectal cancer patients undergoing adjuvant chemotherapy.

bioRxiv · Nov 28, 2022 · PreprintCancer Biology

Temporal inhibition of electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts

Y. Takenaka, I. Inoue, M. Hirasaki, M. Ikeda, Y. Kakinuma

The paper shows that inhibiting mitochondrial respiration with antimycin A reduces stress-induced senescence in human fibroblasts by improving proteostasis.

bioRxiv · Nov 7, 2022Cell Biology

Two DNA binding domains of Mga act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells

K. Uranishi, M. Hirasaki, Y. Kitamura, Y. Mizuno, M. Nishimoto, A. Suzuki, A. Okuda

The paper shows that both DNA-binding domains of Mga repress meiosis-related genes in mouse ESCs, with bHLHZ playing a key role in suppressing Meiosin expression.

bioRxiv · Jul 21, 2020Cell Biology

NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

T. Nakano, I. Inoue, Y. Takenaka, R. Ito, N. Kotani, S. Sato, Y. Nakano, M. Hirasaki, A. Shimada, T. Murakoshi

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.

bioRxiv · Apr 17, 2020Biochemistry