Author

Y. Kalaidzidis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Bioengineering· 1 Biophysics· 1 Pathology· 1

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Research Focus:cell type annotation· 8 Organism:human· 5 Approach:microscopy & imaging analysis· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:imaging· 3 Organism:mouse· 3 Research Focus:spatial domain detection· 3

Frequent Co-Authors

M. Zerial· 8 shared C. Franke· 3 shared F. Segovia-Miranda· 3 shared H. Morales-Navarrete· 3 shared S. Seifert· 3 shared U. Repnik· 3 shared L. Brusch· 2 shared V. Koteliansky· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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8 shared papersCell Biology

M. Zerial

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Hep3D: A 3D single-cell digital atlas of the liver to study spatio-temporal tissue architecture

D. Martinez, V. Maldonado, C. Perez, R. Yanez, V. Candia, Y. Kalaidzidis, M. Zerial, H. Morales-Navarrete, F. Segovia-Miranda

The paper develops Hep3D, a 3D single-cell atlas of the mouse liver, revealing spatiotemporal patterns of cellular structures and the structural role of Kupffer cells in liver homeostasis.

bioRxiv · Jan 21, 2023 · PreprintCell Biology

Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

L. Belicova, U. Repnik, J. Delpierre, E. Gralinska, S. Seifert, J. I. Valenzuela, H. A. Morales-Navarrete, C. Franke, H. Raagel, E. Shcherbinina, T. P. Prikazchikova, V. Koteliansky, M. Vingron, Y. Kalaidzidis, T. Zatsepin, M. Zerial

This study identifies apical bulkheads in hepatocytes as mechanical structures that drive anisotropic lumen expansion during liver development.

Journal of Cell Biology · Jul 30, 2021Peer-reviewedCell Biology

The novel Rab5 effector FERRY links early endosomes with the translation machinery

J. S. Schuhmacher, S. tom Dieck, S. Christoforidis, C. Landerer, J. Davila Gallesio, L. Hersemann, S. Seifert, R. Schaefer, A. Giner, A. Toth-Petroczy, Y. Kalaidzidis, K. E. Bohnsack, M. T. Bohnsack, E. M. Schuman, M. Zerial

This study identifies FERRY as a Rab5 effector that localizes mRNAs and ribosomes to early endosomes, impacting mRNA distribution and causing brain damage when disrupted.

bioRxiv · Jun 20, 2021 · PreprintCell Biology

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

P. Paramasivam, C. Franke, M. Stoeter, A. Hoijer, S. Bartesaghi, A. Sabirsh, L. Lindfors, M. Yanez Arteta, A. Dahlen, A. Bak, S. Andersson, Y. Kalaidzidis, M. Bickle, M. Zerial

The paper visualizes mRNA escape from endosomal recycling tubules using super-resolution microscopy and identifies parameters affecting endosomal escape and cytotoxicity in human cells.

bioRxiv · Dec 18, 2020Bioengineering

Correlative SMLM and electron tomography reveals endosome nanoscale domains

C. Franke, U. Repnik, S. Segeletz, N. Brouilly, J.-M. Verbavatz, Y. Kalaidzidis, M. Zerial

This paper develops a superCLEM workflow combining SMLM and electron tomography to visualize endosome nanoscale domains in HeLa cells, revealing Rab5 organization distinct from cargo molecules.

bioRxiv · May 6, 2019Cell Biology

3D spatially-resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression

F. Segovia-Miranda, H. Morales-Navarrete, M. Kucken, V. Moser, S. Seifert, U. Repnik, F. Rost, A. Hendriks, S. Hinz, C. Rocken, D. Luthjohann, Y. Kalaidzidis, C. Schafmayer, L. Brusch, J. Hampe, M. Zerial

This study creates 3D spatial models of human liver tissue to identify new morphometric parameters and topological defects linked to NAFLD progression.

bioRxiv · Mar 9, 2019Pathology

Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome

L. Goto-Silva, M. P. McShane, S. Salinas, Y. Kalaidzidis, G. Schiavo, M. Zerial

The paper identifies Rab5-APPL1 endosomes as mediators of retrograde Akt1 transport in hippocampal pyramidal neurons.

bioRxiv · Dec 17, 2018Cell Biology

Liquid-crystal organization of liver tissue

H. Morales-Navarrete, H. Nonaka, A. Scholich, F. Segovia-Miranda, W. de Back, K. Meyer, R. L. Bogorad, V. Koteliansky, L. Brusch, Y. Kalaidzidis, F. Julicher, B. M. Friedrich, M. Zerial

The paper reveals that hepatocytes in liver tissue follow a long-range liquid-crystal order, challenging the traditional view of random organization and highlighting bi-directional communication between hepatocytes and sinusoids.

bioRxiv · Dec 13, 2018Biophysics