C. Franke

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.

Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic 'off-the-shelf' regulatory T cell therapy

This study shows that matching or engineering HLA-I and HLA-II improves the efficacy of allogeneic regulatory T cells for immunoregulation.

A Hydroponic-Based Bioassay to Facilitate Plasmodiophora brassicae Phenotyping

This paper develops a hydroponic bioassay to evaluate Plasmodiophora brassicae virulence and canola resistance, offering a reliable and efficient alternative to traditional soil-based methods.

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells

This paper combines CRISPR nucleases to simultaneously knock-in and base edit CAR T cells, reducing translocations to 1.5% and improving safety.

A role for brassinosteroid signaling in decision-making processes in the Arabidopsis seedling

This study identifies brassinosteroid signaling mutants with altered decision-making in Arabidopsis seedlings under resource limitation, showing distinct growth strategies for hypocotyl and root development.

Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

This study identifies apical bulkheads in hepatocytes as mechanical structures that drive anisotropic lumen expansion during liver development.

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

The paper visualizes mRNA escape from endosomal recycling tubules using super-resolution microscopy and identifies parameters affecting endosomal escape and cytotoxicity in human cells.

A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

Unraveling nanotopography of cell surface receptors

The paper introduces a method to map receptor topography on cell surfaces with nanometer precision, demonstrating it on CD4 and CD45 receptors.

Correlative SMLM and electron tomography reveals endosome nanoscale domains

This paper develops a superCLEM workflow combining SMLM and electron tomography to visualize endosome nanoscale domains in HeLa cells, revealing Rab5 organization distinct from cargo molecules.