Author

Y. Kharel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:yeast· 1

Frequent Co-Authors

K. R. Lynch· 2 shared T. Huang· 2 shared A. Gaultier· 1 shared A. J. Mendelson· 1 shared A. Merchak· 1 shared B. E. Isakson· 1 shared C. PaveleciD· 1 shared D. Foster· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

K. R. Lynch

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2 papers

Recent·Most cited

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

K. R. Lynch, Y. Kharel, T. Huang, K. Dunnavant, D. Foster, W. Santos, W. Xu, A. Gaultier, A. Merchak, N. Leitinger, C. Pavelec, S. B. Abbott, G. M. Souza, K. T. Nimchuk, J.-B. Shin, , Z. J. Juskiewicz

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

bioRxiv · Mar 26, 2024 · PreprintPharmacology & Toxicology

Saccharomyces cerevisiae as a platform for assessing sphingolipid kinase inhibitors

Y. Kharel, S. Agah, T. Huang, A. J. Mendelson, P. Barkey-Bircann, O. T. Eletu, J. Gesualdi, J. S. Smith, W. L. Santos, K. R. Lynch

The paper describes a high-throughput assay using Saccharomyces cerevisiae to assess sphingolipid kinase inhibitors and validates it with recombinant enzymes.

bioRxiv · Aug 17, 2017Biochemistry