Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma
Y. L. Cheng, M. A. Banu, W. Zhao, S. S. Rosenfeld, P. Canoll, P. A. Sims
This study uses lineage tracing and scRNA-seq to analyze drug resistance in glioblastoma cells treated with KIF11 inhibitor ispinesib, finding resistance-associated phenotypic changes and potential drug combinations.
bioRxiv · Sep 9, 2023Cancer Biology